Trenton Honda: The epidemiology of UTI and antibiotic resistant uropathogens

Josh Fieggen: Optimizing Early Diagnosis of Multiple Myeloma through Predictive Modelling in the UK Biobank

Cecilia Okusi: avian influenza

PA: Yuliia Kozyntseva

yuliia.kozyntseva@phc.ox.ac.uk

Biography

I trained in medicine at the University of Cape Town, undertook doctoral research at the University of Wales College of Medicine, and studied clinical epidemiology at the University of Toronto. I was appointed Professor of Primary Care in the Nuffield Department of Primary Care Health Sciences at the University of Oxford in 2013.

For many years, I also worked part-time as a salaried GP in the Cynon Valley in South Wales. In 2019, I was named the patient-nominated Royal College of General Practitioners Wales General Practitioner of the Year.

Research

My research focuses on common infections, particularly the appropriate use of antimicrobials, antimicrobial resistance, point-of-care testing, and treatments for viral infections. I also have a longstanding interest in healthcare communication and behaviour change, and am co-author of Motivational Interviewing in Health Care.

I have led or helped lead more than 30 randomised clinical trials in primary care. These include the PRINCIPLE and PANORAMIC adaptive platform trials of community treatments for COVID-19, which together recruited more than 40,000 participants and evaluated nine medicines. I am also coordinator of the European Clinical Research Alliance on Infectious Diseases primary care adaptive platform trial of therapeutics for acute respiratory infections, ECRAID-Prime, and Chief Investigator of SHIELD-1, a trial of peginterferon lambda for acute viral respiratory infections.

I have published more than 500 peer-reviewed papers, including recent trial results in the world’s leading general medical journals. My H-index is over 80. The PACE Study, which evaluated C-reactive protein point-of-care testing to guide antibiotic prescribing for acute exacerbations of COPD, won the Royal College of General Practitioners Research Paper of the Year Award in 2020.

In March 2024, the University of Antwerp conferred on me the degree of Doctor Honoris Causa in Medicine and Health Sciences, recognising my contribution to primary care research in infectious disease management, antimicrobial resistance, pandemic preparedness, and the development of inclusive and efficient primary care research infrastructure.

Supervision

I have supervised 19 doctoral students to successful completion and currently supervise four doctoral students.

Grants and major studies

I have been Chief Investigator or Co-Chief Investigator for the following current or recent studies:

Enhancing host immunity for pandemic preparedness and seasonal respiratory viral infections — SHIELD-1
Funded by the Novo Nordisk Foundation.

European Clinical Research Alliance on Infectious Diseases — Primary Care Adaptive Platform Trial for Pandemics and Epidemics — ECRAID-Prime
EU funded.
https://ecraid.eu/ecraid-prime-work-packages

Platform Adaptive Trial of Novel Antivirals for Early Treatment of COVID-19 in the Community — PANORAMIC
UK funded.
https://www.panoramictrial.org

Platform Community Clinical Trial of Community Treatment for Epidemic and Pandemic Infections — PRINCIPLE
NIHR funded.
https://www.principletrial.org

Platform Randomised Controlled Trial of Point-of-Care Diagnostics for Enhancing the Quality of Antibiotic Prescribing for Community-Acquired Acute Respiratory Tract Infection in Ambulatory Care in Europe — PRUDENCE
EU Innovative Medicines Initiative funded.
https://www.value-dx.eu/index.php/2020/06/26/evaluating-the-clinical-and-cost-effectiveness-of-ca-arti-diagnostics-through-prudence-trial/

General Practitioner Use of a C-Reactive Protein Point-of-Care Test to Help Target Antibiotic Prescribing for Acute Exacerbations of Chronic Obstructive Pulmonary Disease — The PACE Study
NIHR-MRC EME funded.

Antivirals for Influenza-Like Illness? An RCT of Clinical and Cost Effectiveness in Primary Care — ALIC4E
Part of the EU-funded Platform for European Preparedness Against Re-emerging Epidemics consortium.

Probiotics to Reduce Infections in Care Home Residents — PRINCESS
A double-blind randomised controlled trial funded by NIHR.